To Investigate the Role of Memantine as Anxiolytic in Elevated Plus Maze Test and as Antidepressant in Tail Suspension Test in Swiss Albino Mice
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چکیده
منابع مشابه
Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice.
Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects of SB-205384 (0.5-4 mg/kg, i.p.), an alpha3 subunit positive modulator of GABA-A receptor, on anxiety tested in the elevated plus-maze in m...
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متن کامل
Anxiolytic-like effects of olanzapine, risperidone and fluoxetine in the elevated plus-maze test in rats.
In the present study was examined the effect of treatment with olanzapine or risperidone, given separately or in combination with fluoxetine, in the elevated plus-maze test (an animal model of anxiety) in male Wistar rats. The obtained results showed that treatment with olanzapine (1 mg/kg), risperidone (0.1 and 0.3 mg/kg) or fluoxetine (5 and 10 mg/kg) induced an anxiolytic-like effect in the ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2015
ISSN: 2319-2003
DOI: 10.5455/2319-2003.ijbcp20150403